منابع مشابه
Chemokines, chemokine receptors and renal disease.
gesting that, at least in this model, MCP-1 promoted Chemokines are proinflammatory cytokines that funcnearly exclusively tubular epithelial cell damage [5]. tion in leukocyte chemoattraction and activation. There Contrasting with the ample information about chemoare two major families of chemokines, termed CXC and kines and renal injury, so far, little is known about the CC, according to the p...
متن کاملThe role of chemokines in progressive renal disease.
Tubulointerstitial damage followed by scarring and progressive loss of renal function is common to many forms of chronic proteinuric nephropathies. The severity of tubulointerstitial injury and in particular interstitial macrophage infiltration strongly correlate with the risk of renal failure. Proteins filtered through the glomerular capillary in excessive amount activate proximal tubular cell...
متن کاملChemokines in renal diseases.
The interaction of activated leukocytes and renal resident cells is thought to play a crucial role in the pathogenesis of renal diseases. Recent investigations of the pathophysiological roles of chemokines and their cognate receptors have shed light on the detailed molecular mechanisms of leukocyte trafficking and activation in the diseased kidneys. Chemokine/chemokine receptor systems may be e...
متن کاملChemokines, chemokine receptors, and renal disease: from basic science to pathophysiologic and therapeutic studies.
Leukocyte trafficking from peripheral blood into affected tissues is an essential component of the inflammatory reaction to virtually all forms of injury and is an important factor in the development of many kidney diseases. Advances in the past few years have highlighted the central role of a family of chemotactic cytokines called chemokines in this process. Chemokines help to control the sele...
متن کاملIL-10 suppresses chemokines, inflammation, and fibrosis in a model of chronic renal disease.
IL-10 is a pluripotent cytokine that plays a pivotal role in the regulation of immune and inflammatory responses. Whereas short-term administration of IL-10 has shown benefit in acute glomerulonephritis, no studies have addressed the potential benefits of IL-10 in chronic renal disease. Chronically elevated blood levels of IL-10 in rats were achieved by administration of a recombinant adeno-ass...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1997
ISSN: 0085-2538
DOI: 10.1038/ki.1997.90